Dosing & Administration

Administration of Voraxaze

Voraxaze® (glucarpidase) dosing should be adjusted based on patient weight.1
Administer VORAXAZE as a single bolus intravenous injection of 50 U/kg over 5 minutes.1

Weight (lb)1-4445-8889-132133-176177-220221-265266-309310-353†
Weight (kg)≤20>20 to ≤40>40 to ≤60>60 to ≤80>80 to ≤100>100 to ≤120>120 to ≤140>140 to ≤160
Vials
Needed to
Prepare
Dose*		≤1>1 to ≤2>2 to ≤3>3 to ≤4>4 to ≤5>5 to ≤6>6 to ≤7>7 to ≤8

 

Weight (lb)Weight (kg)Vials Needed to Prepare Dose*
1-44≤20≤1
45-88>20 to ≤40>1 to ≤2
89-132>40 to ≤60>2 to ≤3
133-176>60 to ≤80>3 to ≤4
177-220>80 to ≤100>4 to ≤5
221-265>100 to ≤120>5 to ≤6
266-309>120 to ≤140>6 to ≤7
310-353†>140 to ≤160>7 to ≤8
  • *

    Each vial contains 1000 units.

  • †

    Continue to dose patients weighing more than 353 lb according to their weight.

Reconstitution1

  • Reconstitute with 1 mL of sterile saline for injection, USP
  • Roll and tilt the vial gently to mix. Do not shake
  • Inspect the vial and discard VORAXAZE if the solution is not clear, colorless, and free of particulate matter

Storage1

  • Use reconstituted VORAXAZE immediately or store under refrigeration at  36° to 46°F (2° to 8°C) for up to 4 hours if not used immediately
  • VORAXAZE contains no preservative and is supplied as a single-use vial
  • Discard any unused product