Ordering and Reimbursement for Voraxaze

How do I order Voraxaze?

Emergency, Expedited, Urgent Orders – Call ASD at 1-855-786-7292

To order VORAXAZE now and if you have a patient in need, call 1-855-786-7292 to place your order through our Specialty Distributor Partner, ASD Healthcare. ASD has an on-call team available and can process VORAXAZE orders 24/7/365. ASD can process orders for expedited or next-day delivery—same-day emergency delivery is also available; delivery times vary by geography and time of order.

Stocking Orders (Non-Urgent)

VORAXAZE can be ordered through the following distributors.

Note: Orders are drop-shipped only Monday-Thursday for next-day delivery. Expedited delivery is not available.

AmerisourceBergen	1-800-746-6273 AmerisourceBergen.com
Cardinal Health	1-800-926-3161 CardinalHealth.com
McKesson Plasma & Biologics, LLC	1-877-625-2566 Connect.McKesson.com

Consignment

VORAXAZE is available on consignment through the following distributors:

ASD Healthcare	1-855-786-7292 ASDHealthcare.com
Cardinal Health Specialty Pharmaceutical Distribution	1-855-855-0708 or 1-866-677-4844 (after-hours emergency phone) SpecialtyOnline.CardinalHealth.com
FFF Enterprises, Inc.	1-800-843-7477 Biosupply.FFFEnterprises.com

Expert Consensus Guidelines for Stocking Antidotes in Hospitals That Provide Emergency Care

All hospitals that provide emergency care should stock 5 vials of VORAXAZE.¹

View guidelines

VORAXAZE Replacement Policy

SERB Pharmaceuticals has a VORAXAZE Replacement Policy for expired product for purchases made January 1, 2024, and later
The VORAXAZE Replacement Policy can be found here
Additional terms and conditions apply

VORAXAZE Reimbursement

Please call us at 1-844-293-0007 to reach a reimbursement support specialist or email us at serbreimbursement@serb.com and your inquiry will be routed to our reimbursement support team to assist you with any questions you may have about the reimbursement process.

Depending on your patient, when using VORAXAZE, your institution may be eligible for an outlier payment. Please see below information for further details on coding and outlier payments.

Download coding guide

Hospital outlier payment backgrounder

Important Safety Information

Warnings and Precautions

Serious Hypersensitivity Reactions

Serious hypersensitivity reactions, including anaphylactic reactions, may occur. Serious hypersensitivity reactions occurred in less than 1% of patients

Monitoring Methotrexate Concentration/Interference With Assay

Methotrexate concentrations within 48 hours following Voraxaze^® administration can only be reliably measured by a chromatographic method due to interference from metabolites. Measurement of methotrexate concentrations within 48 hours of Voraxaze^® administration using immunoassays results in an overestimation of the methotrexate concentration

Adverse Reactions

In clinical trials, the most common related adverse events (occurring in >1% of patients) were paresthesia, flushing, nausea and/or vomiting, hypotension and headache

Drug Interactions

Voraxaze^® can decrease leucovorin concentration, which may decrease the effect of leucovorin rescue unless leucovorin is dosed as recommended, and may also reduce the concentrations of other folate analogs or folate analog metabolic inhibitors

Indication and limitations of use

Voraxaze^® is a carboxypeptidase indicated to reduce toxic plasma methotrexate concentration (greater than 1 micromole per liter) in adult and pediatric patients with delayed methotrexate clearance (plasma methotrexate concentrations greater than 2 standard deviations of the mean methotrexate excretion curve specific for the dose of methotrexate administered) due to impaired renal function
Limitations of Use: Voraxaze^® is not recommended for use in patients who exhibit the expected clearance and expected plasma methotrexate concentration. Reducing plasma methotrexate concentration in these patients may result in subtherapeutic exposure to methotrexate